Jae Ho Lee

Jae Ho Lee

(Korea)

Education:

Postdoctoral fellow Institute Molecular Medicine and Genetics,
Development of neuroscience program
Medical College of Georgia, (August, GA in US).		 Jan. 2006 – Dec. 2009
Ph.D., Dept. of Biotechnology,
Seoul Women’s University (Seoul, Korea)
Thesis Title: A study on the 3-dimensional spermatogenic cells culture system
for the clinical application		 Feb. 2001 – Feb. 2006
M.S., Dept. of Microbial Engineering,
Kun Kuk University, (Seoul, Korea)
Thesis Title: Development of artificial skin using by tissue engineering		 Mar.1991 – Feb. 1993
B.S. (Honors), Dept. of Biotechnology, Taegu University (Taegu, Korea) Mar.1987 – Feb. 1991

Work Experience:

Associate Professor Department of Biomedical Science, CHA University
(Seongnam, South Korea)		 June 2016 – Present
Research Professor Institute of Tissue Regeneration Engineering
Dankook University (Cheonan, South Korea)		 March 2016 – May 2016
Senior Research Fellow School of Chemical and Biomedical Engineering
Nanyang Technological University (Singapore)		 Aug. 2015 – Feb. 2016
Senior Research Fellow School of Materials Science and Engineering,
Nanyang Technological University (Singapore)		 Jun. 2013 – July 2015
Assistant Professor Dept. Nano Biomedical science,
Dankook University (Cheonan, South Korea)		 Sep. 2012 – Jun. 2013
Full instructor Dept. Nano Biomedical science,
Dankook University (Cheonan, South Korea)		 Jan. 2010 – Sep. 2012
Lab director MDplus infertility clinic center (Seoul, South Korea)
→ Full responsible for clinical lab and base study		 May. 2002 – Dec. 2004
Lab director Mirae and Heemang OB/Gy Clinic center (Seoul, South Korea)
→ Full responsible for clinical lab and base study		 Mar. 2000 – Mar. 2002
Research Scientist Center for Reproduction & Genetics
BunDang Je-Saeng General Hospital (Sungnam, South Korea)
→ Assistant scientist for clinical lab and base study		 May 1998 – Feb. 2000
Researcher Lab of Andrology, Infertility Medical Center,
CHA General Hospital (Seoul, South Korea)
→ Assistant scientist for Andrology lab and base study		 Aug. 1995. – Mar. 1998
Junior Research Scientist Cancer Research Center, College of Medicine,
Seoul National University (Seoul, South Korea)
→ Assistant scientist for hematology-oncology lab		 May. 1993 – Jul. 1993

Teaching Experience

Subject: Stem cell engineering
Department of Nano biomedicine science, Dankook University
→ Responsible for lecture and assessment of around 30 graduate student		 1st Semester, 2013
Subject: Neuronal tissue regeneration medicine
Department of Nano biomedicine science, Dankook University
→ Responsible for lecture and assessment of around 20 graduate student		 2nd Semester 2012
Subject: Dental tissue regeneration medicine
Department of Nano biomedicine science, Dankook University
→ Responsible for lecture and assessment of around 25 graduate student		 2011 ~ 2012
Full semester
Subject: Molecular Genetic
Department of Animal Science, Kun-Kuk university (Seoul, South Korea)
→ Responsible for lecture and assessment of around 40 undergraduate student		 Full semester, 2005
Subject: Biochemistry,
College of Medicine, Pochon CHA University (Seoul, South Korea)
→ Responsible for lecture and assessment of around 50 medical student		 2nd semester 2003
Subject: Molecular Breeding Science, General Biology
Department of Animal Science, Sahmyook College, Seoul, Korea
→ Responsible for lecture and assessment of around 50 undergraduate student		 2001 ~ 2005
Full semester

Publications

  1. Myung Joo Kim, Young Sang Kim, Yu Jin Kim, Hye Ran Lee, Kyoung Hee Choi, Eun A Park, Ki Ye Kang, Tae Ki Yoon, Sohyun Hwang, Jung Jae Ko, You Shin Kim, and Jae Ho Lee. Upregulation of Low-Density Lipoprotein Receptor of the Steroidogenesis Pathway in the Cumulus Cells Is Associated With the Maturation of Oocytes and Achievement of Pregnancy. Cells 11-Sep-2021. 10, 2389 (ISSN 2073-4409, IF 6.600)
  2. In-Young Choi, Jae Hyuk Shim, Mi-Hye Kim, Won Dong Yu, Yu Jin Kim, Gain Choi, Jae Ho Lee*, Hee Jung Kim*, Kyung-Ok Cho* Truncated neogenin promotes hippocampal neuronal death after acute seizure. Neurosciences accept 1-July-2021. (ISSN: 0306-4522, IF 3.056)
  3. Wondong Yu, Yu Jin Kim, Min Jeong Cho, Gi Jin Kim1, Soon Ha Kim, Myung Joo Kim, Jung Jae Ko, Jae Ho Lee. MIT-001 Restores Homeostasis of TNF-α and IFN-γ-Exposed Human Placenta-Derived Mesenchymal Stem Cells by Enhancing Mitochondrial Quiescence and Cytoskeletal Organization. International Journal of Molecular Sciences 2021, 22(10), 5062 (ISSN 1422-0067, IF 4.556)
  4. Yu Jin Kim, YoungJoon Park, Yeo Reum Park, Young Sang Kim, Hye Ran Lee, Sang Jin Lee, Myung Joo Kim*, KyuBum Kwack*, Jung Jae Ko*, Jae Ho Lee*. Role of RGMc as a neogenin ligand in follicular development in the ovary. Biomedicines, 2021, 9, 280. (ISSN 2227-9059, IF 4.717)
  5. Wondong Yu, Yu Jin Kim, Min Jeong Cho, Jin Seok, Gi Jin Kim, Chang-Han Lee, Jung Jae Ko*, You Shin Kim*, Jae Ho Lee*. The mitochondrial-derived peptide MOTS-c restores homeostasis in aged human placenta-derived mesenchymal stem cells in vitro. Mitochondrion, 2021 Feb 24; 58:135-146. doi: 10.1016/j.mito.2021.02.010 (ISSN: 1567-7249. IF 3.992)
  6. Won-Yong Jeon, Seyoung Mun, Wei Beng Ng, Keunsoo Kang, Kyudong Han, Sohyun Hwang, Hyug-Han Kim, and Jae Ho Lee. Modulation of human mesenchymal stem cells by electrical stimulation using an enzymatic biofuel cell. Catalysts, 2021, 11(1), 62 (ISSN: 2073-4344, IF 3.520)
  7. Young Sang Kim, Yu Jin Kim, Myung Joo Kim, Sang Jin Lee, Hwang Kwon, Jae Ho Lee. Novel Medicine for Endometriosis and Its therapeutic effect in a mouse model, Biomedicines, 2020 Dec 16;8(12):619. (ISSN 2227-9059, IF 4.717)
  8. Won Sik Jang, Ki Hong Kim, Kyoung Taek Lim, Jongsoo Lee, Ju Eun Heo, Hyojeong Kwon, Hyoeun Kang, Jae Ho Lee, Seung-Ah Choe, Dae Kun Kim. ”External validation of the post-varicocele repair semen analysis nomogram to predict total motile sperm count: a multicenter study. Andrologia. 2020 Dec;52(11):e13809. (ISSN:1439-0272 IF 1.951)
  9. Tai Eun Shin, Jin Woo Park, Won-Yong Jeon, Eun Ji Lee, Hyojeong Kwon, Boyoung Jeon, Hyo Eun Kang, Myung Joo Kim, Dae Keun Kim, Hyug-Han Kim, Jung Jae Ko, and Jae Ho Lee. Motility enhancement of human spermatozoa using electrical stimulation in the nano-Ampere range with enzymatic biofuel cells. PLoS One. 2020 Feb 20;15(2): e0228097 (ISSNL: 1932-6203 IF 2.740)
  10. Myung Joo Kim, Kyoung Hee Choi, Dong Woo Seo, Hye Ran Lee, Hyun Seok Kong, Chan Hee Lee, Woo Sik Lee, Hoon Taek Lee, Jung Jae Ko, Ji Hyang Kim, Sang Jin Lee, Jae Ho Lee. Association between functional activity of mitochondria and actin cytoskeleton instability in oocytes from advanced age mice. Reproductive Sciences. 2020 Apr;27(4):1037-1046 (ISSN: 1933-7191 IF 2.616)
  11. Divakarla SK, Yamaguchi S, Kokubo T, Han DW, Lee JH, Chrzanowski W. Improved bioactivity of GUMMETAL®, Ti59Nb36Ta2Zr3O0.3, via formation of nanostructured surfaces. J Tissue Eng. 2018 May 15;9:2041731418774178. doi: 10.1177/2041731418774178. eCollection 2018 Jan-Dec. IF: 4.148
  12. Namgue Hong, Mi-Hye Kim, Churl K. Min, Hee Jung Kim, Jae Ho Lee. The co-expression of Neogenin with SOX2 in hippocampal neurons. Biochemical and Biophysical Research Communications 2017. August 19. 490(2), 453–459.
  13. Soon-Jung Park, Ki-Hoon Kim, Won-Yong Jeon, Joseph Seo, Jung-Min Han, Jong-Soo Kim, Hyung-Min Chung, Jae Ho Lee*, Sung-Hwan Moon, Hyug-Han Kim. Enzyme catalyzed electrostimulation of human embryonic stem cell-derived cardiomyocytes influence contractility and synchronization. Biochemical Engineering Journal. Doi: doi.org/10.1016/j.bej.2017.03.013. 123 (2017) 95–109 (SCI: 1369-703X: IF. 2.463) *corresponding author
  14. Lee BH, Shirahama H, Kim MH, Lee JH, Cho NJ, Tan LP Colloidal templating of highly ordered gelatin methacryloyl-based hydrogel platforms for three-dimensional tissue Analogues. NPG Asia Materials. 2017. Feb. (SCIE: 1884-4049, IF 8.772)
  15. Kyong Hee Choi, Sun Haw Hong, Hye Ran Lee, Hoon Taek Lee*, Jae Ho Lee*, Sang Jin Lee*. Neogenin regulates mitochondrial activity in pre-implantation mouse embryos. Biochem Biophys Res Commun. 2017 Jan 22; 482(4):1060-1066. (SCI: 0006-291X: IF 2.281) *corresponding author
  16. Yan Wang*, Jae-Ho Lee*, Hitomi Shirahama, Jeongeun Seo, Jeffrey S. Glenn and Nam-Joon Cho. Extracellular matrix functionalization and huh-7.5 Cell co-culture promote the hepatic differentiation of human adipose-derived mesenchymal stem cells in a 3D ICC hydrogel scaffold. ACS Biomater. Sci. Eng., 2016-Oct-19, 2(12): 2255-2265. (SCI: 2373-9878; IF3.234)
  17. Yan Wang, Myung Hee Kim, Hitomi Shirahama, Jae Ho Lee, Soon Seng Ng, Jeffrey S. Glenn & Nam-Joon Cho. ECM proteins in a microporous scaffold influence hepatocyte morphology, function, and gene expression. Sci Rep. 2016 Nov 29 (6) 37427. doi: 10.1038/srep37427 (SCIE: 2045-2322, IF: 5.525)
  18. Mundargi RC, Potroz MG, Park JH, Seo J, Lee JH, Cho NJ. Extraction of sporopollenin exine capsules from sunflower pollen grains. RSC Advances doi: 10.1039/C5RA27207F. 2016, Feb-9 6:16533-16539.
  19. Mundargi RC, Potroz MG, Park SH, Park JH, Shirahama H, Lee JH, Seo J, Cho NJ. Lycopodium Spores: A Naturally Manufactured, Superrobust Biomaterial for Drug Delivery. Advanced Functional Materials 2016 (26) 487-497. (SCI: 1616-3028: IF 10.439)
  20. Mundargi RC, Potroz M, Park JH, Seo JE, Ee-Lin Tan, Lee JH and Cho NJ. Eco-friendly streamlined process for sporopollenin exine capsule extraction. Scientific report 2016 Jan 28;6: 19960 (SCIE: 2045-2322, IF: 5.525)
  21. Shirahama H, Kumar SK, Jeon WY, Kim MH, Lee JH, Ng SS, Tabaei SR, Cho NJ. Fabrication of Inverted Colloidal Crystal Poly(ethylene glycol) Scaffold: A Three-dimensional Cell Culture Platform for Liver Tissue Engineering. J Vis Exp. 2016 Aug 27;(114). IF: 1.325
  22. Jae Ho Lee, Yong Il Choi, Sung Sook Choi, Hae-Won Kim, Churl K Min, Sang Jin Lee. a loss- and gain-of-function approach to investigate early cell fate determinants in preimplantation mouse embryos. Journal of Visualized Experiments. 2016 Jun. 6; (112) (IF: 1.325, ISSN: 1940-087X)
  23. Kim MH, Kumar SK, Shirahama H, Seo J, Lee JH, Zhdanov VP, Cho NJ. Biofunctionalized hydrogel microscaffolds promote three-dimensional hepatic dheet morphology. Macromolecular Bioscience 2016 Mar;16(3):314-21. (ISSN: 1616-5187 SCI, IF 3.650)
  24. Mundargi RC, Potroz M, Park SH, Shirahama H, Lee JH, Seo JE, Cho NJ. Natural sunflower pollen as a drug delivery vehicle. Small. 2016 Mar; 12(9):1167-73. (ISSN: 1613-6829, IF 8.368).
  25. Ing Loon Sean Chua, Hae-Won Kim, Jae Ho Lee. Signaling of extracellular matrices for tissue regeneration and therapeutics. Tissue Engineering and Regenerative Medicine. 2016, Feb Volume 13, Issue 1, 1-12 (SCIE: 1738-2696: IF 1.088)
  26. Kim MH, Kumar SK, Shirahama H, Seo J, Lee JH, Cho NJ. Phenotypic regulation of liver cells in a biofunctionalized three-dimensional hydrogel platform. Integr Biol (Camb). 2016 Feb 15; 8(2): 156-166. (ISSN: 1757-9694 IF 3.756)
  27. Jae Ho Lee, Won-Yong Jeon, Hyug-Han Kim, Eun-Jung Lee, Hae-Won Kim. Electrical stimulation by enzymatic biofuel cell to promote proliferation, migration and differentiation of muscle precursor cells. Biomaterials 2015 July 53:358-369 (SCI: 0142-9612: IF 8.557)
  28. Bae Hoon Lee, Myung Hee Kim, Jae Ho Lee, Dror Seliktar, Nam Joon Cho, Lay Poh Tan. Modulation of Huh 7.5 spheroid formation and functionality using modified PEG-based hydrogels of different stiffness. PloS one 2015 Feb 18;10 (2):e0118123. (SCIE:: 1932-6203: IF 3.534)
  29. Jae Ho Lee, Ahmed El-Fiqi, Cheol-Min Han, Hae-Won Kim Physically-strengthened collagen bioactive nanocomposite gels for bone: A feasibility study. Tissue Engineering and Regenerative Medicine 2015 January. 12: 1-8. (SCIE: 1738-2696: IF 1.088)
  30. Wojciech Chrzanowski, Jae Ho Lee, Alexey Kondyurin, Megan S. Lord, Jun-Hyeog Jang, Hae-Won Kim, and Marcela M.M. Bilek. Nano-bio-chemical braille for cells – the regulation of stem cell responses using bi-functional surfaces. Advanced functional materials 2015, Jan-14;25(2):193–205 (SCI: 1616-3028: IF 10.439)
  31. Lee Jae Ho, Ja-Yeon Lee, Sung Hee Yang, Eun-Jung Lee, Hae-Won Kim. Carbon nanotube – collagen three-dimensional culture of mesenchymal stem cells promotes expression of neural phenotypes and secretion of neurotrophic factors. Acta Biomaterialia. 2014 Oct; 10(10):4425-36. (SCI: 1742-7061:IF 6.025)
  32. Jae Ho Lee, Sung Sook Choi, Hae-Won Kim, Wen Cheng Xiong, Churl K. Min, Sang Jin Lee. Neogenin as a receptor for early cell fate determination in preimplantation mouse embryos. PloS One 2014 Jul 11;9(7):e101989. (SCIE: 1932-6203: IF 3.534)
  33. Jin Wan Park, Yun Dan Kang, Jong Soo Kim, Jae Ho Lee,* Hae-Won Kim. 3D microenvironment of collagen hydrogel enhances the release of neurotrophic factors from human umbilical cord blood cells and stimulates the neurite outgrowth of human neuronal precursor cells. Biochemical and Biophysical Research Communications 2014 May 9; 447: 400–406. (SCI: 0006-291X: IF 2.281) *corresponding author
  34. Singh RK, Patel KD, Lee JH, Lee EJ, Kim JH, Kim TH, Kim HW. Potential of magnetic nanofiber scaffolds with mechanical and biological properties applicable for bone regeneration. PLoS One. 2014 Apr 4;9(4):e91584 (SCIE: 1932-6203) (SCIE: 1932-6203:IF 3.534)
  35. Lee JH, Park JH, El-Fiqi A, Kim JH, Yun YR, Jang JH, Han CM, Lee EJ, Kim HW. Biointerface control of electrospun fiber scaffolds for bone regeneration: Engineered protein link to mineralized surface. Acta Biomaterialia. 2014 Jun 10(6):2750-61. (SCI: 1742-7061:IF 6.025)
  36. Perez R, Kim M, Kim TH, Kim JH, Lee JH, Park JH, Knowles JC, Kim HW. Utilizing core-shell fibrous collagen-alginate hydrogel cell delivery system for bone tissue engineering. Tissue Eng Part A. 2014 Jan; 20(1-2):103-114. (SCI: 1937-3341:IF 4.254)
  37. Jae Ho Lee, Jeong-Hui Park, Mohamed Eltohamy, Roman Perez, Eun-Jung Lee and Hae-Won Kim. Collagen gel combined with mesoporous nanoparticles loading nerve growth factor as a feasible therapeutic three-dimensional depot for neural tissue engineering. RSC Advances 2013(Jul); 3:24202–24214 (SCIE: 2046-2069: IF 3.708)
  38. El-Fiqi A, Lee JH, Lee EJ, Kim HW Collagen hydrogels incorporated with surface-aminated mesoporous nanobioactive glass: improvement of physicochemical stability and mechanical properties effective for hard tissue engineering. Acta Biomaterialia. 2013 Dec; 9(12):9508-95021 (SCI: 1742-7061: IF 6.025)
  39. Hyung-seok Park, Myoung-Seon Gong, Ivan wall, Hae-Won Kim, Jae Ho Lee*, Jonathan C*. Knowles. Silk fibroin-polyurethane blends: physical properties and effect of silk fibroin content on biocompatibility and myoblast differentiation. Acta Biomaterialia. 2013 Nov; 9(11):8962-71.(*Co-corresponding author) (SCI: 1742-7061:IF 6.025)
  40. Jae Ho Lee, Jeong-Hui Park, Ye-Rang Yoon, Jun-Hyeog Jang, Eung-Jung Lee, Wojciech Chranowski, Ivan Wall and Hae-Won Kim. Tethering bi-functional protein onto mineralized polymer scaffolds to regulate mesenchymal stem cell behaviors for bone regeneration. RSC Journal of Materials Chemistry B. 2013; 1(21); 2731-41. (SCI: 2050-750X: IF 6.662)
  41. Chrzanowski W, Kondyurin A, Lee JH, Lord MS, Bilek MM, Kim HW. Biointerface protein enhanced stem cells binding to implant surfaces for improved osteointegration. Journal of Materials Science: Materials in Medicine, 2012 Sep; 23(9):2203-15. (SCIE: 0957-4530: IF 2.379)
  42. Sun Ae Oh, Hye Young Lee, Jae Ho Lee, Tae Hyun Kim, Jun Hyeog Jang; Hae Won Kim, Ivan Wall. Collagen three dimensional hydrogel matrix carrying basic fibroblast growth factor for the cultivation of mesenchymal stem cells and osteogenic differentiation. Tissue engineering. Part A 2012 Jan. 18(9~10):1087-1100. (SCI: 1937-3341:IF 4.254)
  43. Jae Ho Lee, Hye-Young Lee, Hae-Won Kim. Adhesive proteins linked with focal adhesion kinase regulate neurite outgrowth of PC12 cells. Acta Biomaterialia. 2012 Jan, 8(1):165–172 (SCI: 1742-7061, IF 6.025)
  44. Jae Ho Lee, Hee Jung Kim, Myung Whan Suh, Seung Cheol Ahn. Sustained Fos expression is observed in the developing brainstem auditory circuits of kanamycin treated rats. Neuroscience letters. 2011 Nov 14; 505(2):98-103. (SCI: 0304-3940:IF 2.055)
  45. David Brindley, Kishaani Moorthy, Jae Ho Lee, Chris Mason, Hae-Won Kim and Ivan Wall. Bioprocess forces and their impact on cell recovery, viability, proliferation and osteogenic differentiation: implications for bone regeneration therapy. Journal of Tissue Engineering. 2011 June. 17. In press.
  46. Jae Ho Lee, Hae Won Kim. Tissue regeneration and important of extracellular matrices Korea Society for Biochemistry and Molecular Biology 2011 Sept. 31(3): 40-48
  47. Hae Hyoung Lee, Ueon Sang Shin, Jae Ho Lee, Hae Won Kim. Biomedical nanocomposites of poly (lactic acid) and calcium phosphate hybridized with modified carbon nanotubes for hard tissue implants. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2011 Aug; 98B(2):246-54. (SCI: 1552-4981: IF 2.328)
  48. Jae Ho Lee, Hye Sun Yu, Gil Su Lee, Aer i Ji, Jung Keun Hyun, Hae Won Kim. Collagen gel three dimensional matrices combined with adhesive proteins stimulate neuronal differentiation of mesenchymal stem cells. Journal of the Royal Society Interface. 2011 Jul 6;8(60):998-1010. (SCI: 1742-5689: IF 3.856)
  49. Ning Xu, Hyung Goo Kim, Balasubramanian Bhagavath, Sung Gyu Cho, Jae Ho Lee, Kyungsoo Ha, Irene Meliciani, Wolfgang Wenzel, Robert S. Podolsky, Lynn P. Chorich, Kathryn A. Stackhouse, Anna M.H. Grove, Lawrence N. Odom, Metin Ozata, David P. Bick, Richard J. Sherins, Soo Hyun Kim, Richard S. Cameron, Lawrence C. Lyman. Nasal Embryonic LHRH Factor (NELF) Mutations in Patients with Monogenic Normosmic Hypogonadotropic Hypogonadism and Digenic Kallmann Syndrome. Fertility and Sterility 2011 Apr; 95(5):1613-1620. (SCI: 0015-0282: IF 4.295)
  50. Jae Ho Lee, Jonu Pradhan, Dhiraj Maskey, Ki Sup Park, Sung Hwa Hong, Myung Whan Suh, Myeung Ju Kim, and Seung Cheol Ahn. Glutamate co transmission from developing medial nucleus of the trapezoid body lateral superior olive synapses is cochlear dependent in kanamycin treated rats. Biochemical and Biophysical Research Communication. 2011 Feb 11; 405(2):162-167. (SCI: 0006-291X: IF 2.281)
  51. Jae Ho Lee, Jeong Hyun Oh, Jae Hoon Lee, Mi Ran Kim and Churl K. Min. Evaluation of in vitro spermatogenesis using poly (D,L lactic co glycolic acid) (PLGA) based macroporus biodegradable scaffolds. Journal of Tissue Engineering and Regenerative Medicine 2011 Feb; 5(2):130-137. (SCI: 1932-7005: IF 4.428)
  52. Lee JH, Ahn HJ, Lee SJ, Gye MC, Min CK. Effects of L and T type Ca(2+) channel blockers on spermatogenesis and steroidogenesis in the prepubertal mouse testis. Journal of Assisted Reproduction and Genetics. 2011 Jan; 28(1):23-30. (SCIE: 1058-0468: IF 1.772)
  53. Jae Ho Lee, Jong Uk Kim, So Yeon Lee, Churl K. Min. Inhibitory actions of mibefradil on steroidogenesis in mouse Leydig cells: involvement of Ca2+ entry via the T type Ca2+ channel. Asian Journal of Andrology 2010 Nov; 12(6):807-813. (SCI: 1008-682X: 2.530)
  54. Jae Ho Lee, Myung C. Gye, Kyoo Wan Choi, Jae Yup Hong, Yong Bok Lee, Dong-Wook Park, Seung Jae Lee and Churl K. Min. In vitro differentiation of germ cells from nonobstructive azoospermic patients using three-dimensional culture in collagen gel matrix. Fertility and Sterility, 2007, April; 87(4):824-33. (SCI: 0015-0282: IF 4.295)
  55. Jae Ho Lee, Hyun Joo Kim, Haekwon Kim, Sang Jin Lee and Myung Chan Gye. In vitro spermatogenesis by three-dimensional culture of rat testicular cells in collagen gel matrix. Biomaterials, 2006, 27(14): 2845-2853. (SCI: 0142-9612: IF 8.312)
  56. Lee JH, Kim H, Kim DH, Gye MC. Effects of calcium channel blockers on the spermatogenesis and gene expression in peripubertal mouse testis. Systems Biology in Reproductive Medicine 2006, 52(4):311-8. (SCI: 1939-6368L IF 1.700)
  57. JH Lee, SJ Lee, KW Choi, SJ Lee, and MC Gye. Expression of beta catenin in human testes with spermatogenic defects. Systems Biology in Reproductive Medicine 2005, 51: 271-276. (SCI: 1939-6368: IF 1.700)
  58. Son WY, Han CT, Lee JH, Jung KY, Lee HM, Choo YK. Developmental expression patterns of alpha1H T type Ca2+ channels during spermatogenesis and organogenesis in mice. Dev Growth Differ 2002, 44, 181-190.
    56. Son WY, Lee JH, Lee JH, Han CT. Acrosome reaction of human spermatozoa is mainly mediated by alpha1H T-type calcium channels. Mol Hum Reprod. 2000, 6, 893-897.
  59. Son W.Y. Han C.T., Hwang S.H., Lee J.H., Kim S., Kim Y.C. (2000) Repression of HspA2 mRNA in human testes with abnormal spermatogenesis. Fertil Steril. 73, 1138-44.
  60. Weon-Young Son, Suh-ha Hwang, Ching-Tack Han, Jae Ho Lee, Seokjoong Kim and Young Cha Kim. (1999) Specific expression of heat shock protein HspA2 in human male germ cells. Molecular Human Reproduction 5, 1122-1126.

Abstracts and Presentations:

  1. Yu Jin Kim, Kyong Hye Choi, Ki Ye Kang, Hyun Soo Kim, HyeJin Jeong, Hyoeun Kang, Yeo Reum Park, Myung Ju Kim, Su Jung Kim, Min kyung Kwon, Hye Ok Kim, Mi Kyung Koong, Yu Shin Kim, Tae Ki Yoon, Jung Jae Ko, Jae Ho Lee. A new role of Repulsive Guidance Molecule C as a ligand of neogenin enhanced in follicular development of ovary in the mouse. ESHRE 2020
  2. Hyojeong Kwon, Boyoung Jeon, EunJi Lee, Hyoeun Kang, Tai Eun Shin, Jung-Jae Ko, Kyu Bum Kwack, Jae Ho Lee, Dae Keun Kim. Predictive biomarker as microbiomes in the seminal plasma associated with spermatogenesis status. American Society Reproductive Medicine (ASRM) 2019. October 12-16, Philadelphia, US.
  3. Hyoeun Kang, Hyojeong Kwon, Bo Young Jeon, Eun Jin Lee, TaiEun Shin, Jung-Jae Ko, Dae Keun Kim, Wojciech Chrzanowski, Jae Ho Lee. Impact of nanoparticles on motility of human spermatozoa. American Society Reproductive Medicine (ASRM) 2019. October 12-16, Philadelphia, US.
  4. Hye Ran Lee, Myung Joo Kim, Kyoung Hee Choi, Ji Hyang Kim, Chang Han Park, Nah Kim, Mi Kyong Koong, Tae Ki Yoon, Sang Jin Lee, Jae Ho Lee. Functional activity of mitochondria in aged oocytes is associated with cytoskeleton stability in mice. American Society Reproductive Medicine (ASRM) 2019. October 12-16, Philadelphia, US.
  5. J.I. Baek, Y.E. Lee, H.R. Lee, K.H. Choi, B. Jeon, J.W. Park, M. Kim, H. Lee, Y.B. Lee, Y.S. Kim T.K. Yoon, J.H. Lee. Sperm motility factor using CASA is related to PGS outcome. European Society of Human Reproduction and Embryology (ESHRE) 2019. June 23-26. Vienna, Austria
  6. Y.J. cho M.Sc., E.A. Park, H.S. Kim, J.W. Park, B.Y. Kim, W.Y. Jo, H.Y. Lee, J.H. Lee, K.A. Lee, E.J. Yu5, R. Kim, Y.B. Lee, Y.S. Kim, M.K. Koong, I.S. Kang. Success rates of hatching/hatched blastocyst transfer in frozen embryo transfer (FET) cycles. European Society of Human Reproduction and Embryology (ESHRE) 2019. June 23-26. Vienna, Austria
  7. Jin Woo Park, Chan Hee Lee, Jung-Jae Ko, Dae Keun Kim, Sang Jin Lee, Jae Ho Lee. New role of neogenin in the mammalian testis at the early phase of spermatogenesis. European Society of Human Reproduction and Embryology (ESHRE) 2019. June 23-26. Vienna, Austria
  8. Jin Woo Park, Hyojeong Kwon, Bo Young Jeon, Eun Jin Lee, TaiEun Shin, Jung-Jae Ko, Dae Keun Kim, Jung Kyu Choi, Jae Ho Lee. Cervical environment mimics sperm chip for high performance in isolating sperm from raw semen. European Society of Human Reproduction and Embryology (ESHRE) 2019. June 23-26. Vienna, Austria
  9. Min Jee Kim, Sun Ok Park, MiJin Kim, Ye Seul Hong, Ye-Seul Kim, Eun Bee Joe, Yoon Jeoug Cho, Eun A Park, Jae Ho Lee, Ran Kim, Yubin Lee, Tae Ki Yoon, Inn Soo Kang. Efficacy of whole genome amplification (WGA) and nested PCR methods for single cell analysis in preimplantation genetic diagnosis (PGD) for monogenic diseases. European Society of Human Reproduction and Embryology (ESHRE) 2019. June 23-26. Vienna, Austria
  10. Kyuong Hee Choi, Hye Ran Lee, Dong Woo Seo, Na Kyong Kim, Mi Kyong Koong, Tae Ki Yoon, Hoon Taek Lee*, Jae Ho Lee*, Sang Jin Lee* The motility and localization of mitochondria related with the maturation of advanced age oocytes. European Society of Human Reproduction and Embryology (ESHRE) 2018 July 1-4, Barcelona, Spain
  11. Eunji Lee, Tai Eun Shin, Jinwoo Park, Hyojeong Kwon, Boyoung Jeon, Hyoeun Kang, Gi Yae Kang, Yoon Jeong Cho, Dae Keun Kim, Yoo Shin Kim, Inn Su Kang, Mi Kyoung Koong, Tae Ki Yoon, and Jae Ho Lee. Low progression of sperm motility kinetics related aneuploidy ratios of a fertilized embryo. European Society of Human Reproduction and Embryology (ESHRE) 2018 July 1-4, Barcelona, Spain
  12. Eun A Park, Yoon Jeong Cho, Ju Young Lee, Song Yi Moon, Kyoung Hee Choi, Bo Yeun Kim, Jae Ho Lee, You Shin Kim, Mi Kyoung Koong, Inn Soo Kang, Tae Ki Yoon. Optimal timing of trophectoderm biopsy for preimplantation genetic screening. European Society of Human Reproduction and Embryology (ESHRE) 2018, July 1-4, Barcelona, Spain
  13. Ki Ye Kang, Bo Yeun Kim, Jin Woo Park, Eun Bee Jo, Kyoung Hee Choi, Hwa Hyung Kang, Eun A Park, Jae Ho Lee, Dae Keun Kim,You Shin Kim, Mi Kyoung Koong, Inn Soo Kang, Tae Ki Yoon. Testicular sperm of severe oligo- cryptozoospermia patient improve clinical outcomes compared with ejaculated sperm. European Society of Human Reproduction and Embryology (ESHRE) 2018 July 1-4, Barcelona, Spain
  14. Hye Ran Lee, Kyoung Hee Choi, Eun A Park, Ki Yae Kang, Bo Yeun Kim, Myung Joo Kim, Young Sang Kim, Mi Kyoung Koong, Yu Sin Kim, Tae Ki Yoon, Sohyun Hwang, Jae Ho Lee. Whole mRNA profile in human cumulus cells according to the age and clinical pregnancy. American Society Reproductive Medicine (ASRM) 2018 Oct 8-10, Denver, US
  15. Eun Sun Kim, Kyoung Hee Choi, Eun A Park, Yoon Jeong Cho, Ju Young Lee, Song Yi Moon, Bo Yeun Kim, Young Sang Kim, You Shin Kim, Mi Kyoung Koong, Inn Soo Kang, Tae Ki Yoon, Jae Ho Lee. Age of Women, the AMH Level and the Number of Oocytes has Co-related with Aneuploidy Ratios as Preimplantation Genetic Screening (PGS) Indicator. American Society Reproductive Medicine (ASRM) 2018, Oct 8-10, Denver, US
  16. H.R. LEE, S.H. Hong, S.J. Lee, M. Kim, K.H. Choi, J.H. Lee. The motility and number of mitochondria in the advanced age embryos. European Society of Human Reproduction and Embryology (ESHRE) 2017, July 2-5, Geneva, Switzerland.
  17. Eun A Park, Yoon Jeong Cho, Ju Young Lee, Song Yi Moon, Kyoung Hee Choi, Bo Yeun Kim, Jae Ho Lee, You Shin Kim, Mi Kyoung Koong, Inn Soo Kang, Tae Ki Yoon Long-term vapor storage in liquid nitrogen for human vitrified embryos (ESHRE) 2017, July 2-5, Geneva, Switzerland.
  18. EunJi Lee, Taieun Shin, Jin Woo Park, Hyojeong Kwon, Boyoung Jeon, Dae Keun Kim, Tae Ki Yoon, and Jae Ho Lee. Nanoscale electrical stimulation of the enzymatic biofuel cell promote motility of the human spermatozoa. American Society Reproductive Medicine (ASRM) 2017, Oct 28 – Nov 1, San Antonio, US
  19. Kyoung Hee Choi, Eun A Park, Yoon Jeong Cho, Hyo Sun Choi, Seung-Ah Choe, Ran Kim, Tae Ki Yoon, Inn Soo Kang, Mi Kyoung Koong, You Shin Kim, Chae Hee Sim, Dong Soo Park, Jae Ho Lee, Jayeon Kim. Efficacy of freeze-all embryo transfer in IVF cycles with late-developing blastocyst(s): improve the asynchrony between the embryo and endometrium. American Society Reproductive Medicine (ASRM) 2017 Oct 28 – Nov 1, San Antonio, US.
  20. Park J.W., Kang Y.D., Kim J.S., Kim HW, Lee JH 3D microenvironment of collagen hydrogel enhances the release of neurotrophic factors from human umbilical cord blood stem cells and stimulates the neurite outgrowth of human neuronal precursor cells. World Congress Regenerative Medicine 2015, Leipzig, Germany.
  21. Jae Ho Lee, Sung Sook Choi, Hae-Won Kim, Wen Cheng Xiong, Churl K. Min, Sang Jin Lee. Neogenin as receptor for the early cell fate determination in preimplantation mouse embryos. The 2014 American Society for Cell Biology (ASCB)/ifcb meeting, Philadelphia. US.
  22. Jae Ho Lee, Seong-Oh Kim, Won Yong Jeon, Myung Hee Kim, Nam-Joon Cho. The biochemical and mechanical characterization of tumorigenic cell induced by paraformaldehyde. Asia Korean Conference 2013 (Singapore)
  23. Jae Ho Lee, Hye young Lee, Hae won Kim. Effects of Adhesion Proteins on Neural Cell Behaviors. The 9th world biomaterials congress. 2012 (Chenddu, China)
  24. Jae Ho Lee, Tsetseg Badam, Hye Young Lee, Hye Sun Yu, Hae Won Kim. Utilizing Collagen based Hydrogel Matrices in Neural Cell Differentiation. The 3rd Asian Biomaterials Congress. 2011. (Busan, South Korea)
  25. Jae Ho Lee, Hye Sun Yu, Sun Young Nam, Jung Keun Hyun, Hae Won Kim. A neuronal potential of mesenchymal stem cells within three-dimensional gel matrix. The 23rd European Conference on Biomaterials. 2010. (Tampere, Finland)

Patent

  1. Wen Cheng Xiong, Jae Ho Lee, Lin Mei. Netrin 1 as a potential target for diagnosis and treatment of male
    fertility and infertility associated disorders, Medical College of Georgia,
    US Patent. No. PCT/US2008/082238. Apr. 29. 2010
  2. HW Kim, JH Lee, JH Jang. Fibronectin-Osteocalcin fusion protein coated scaffold for bone regeneration.
    Patent No. 10-2012-0066411. 20-June-2012
  3. HW Kim, JH Jang, YY Rang, JH Lee, JH Kim. Fusion protein for dental and bone regeneration.
    Patent No. 10-1234361.
  4. Chul K Min, SJ Lee, JH Lee. Inducer of stem cells as RGMc and Induction methods of stem cells.
    Patent No. 10-1638403. 5-July-2016
  5. HH Kim, HW Kim, JH Lee. Electrical stimulation for control of cell behavior base on enzymatic biofuel Cell.
    Patent No.10-2013-0066156 5-Sep-2017
  6. CK Min, SJ Lee, JH Lee. RGMc Media composition for inducing stem cell comprising repulsive guidance molecule c and method for inducing stem cell using the composition. 10-163840. 07-05-2016
  7. Hee Jung Kim, Nam Gue Hong, Jae Ho Lee. Culture media composition for promoting neuronal stem cell proliferation and maintaining neuronal stem cell capacity comprising neogenin. 10-2018-0067289, 12-June-2018
  8. Kyong Oak Cho, Hee Jung Kim, Jae Ho Lee. Use of neogenin as a diagnostic marker for brain injury caused by Epilepsy. 2019-072542-0, 15-May-2021

Principal investigator: Research grant

National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology: The Basic Science Research Program (2013R1A1A4A01012572) support June-2012 ~ June 2016
Project title: Mesenchymal stem cell isolation from umbilical cord blood by the collagen gel and nerve degeneration therapy by induced neurotrophic factors (Funds: $138,000 for 4 years)
National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology: The Basic Science Research Program (2019R1A2C1086882) support June-2019 ~ June 2022
Project title: Fallopian tube mimic culture system for pre-implantation embryo culture (Funds: $150,000 for 3 years)

Awards

R-Award, Korea Society of Reproductive medicine. 2019
Springer Nature Award 2016
Promising young scientist award,
European Society of Human Reproduction and Embryology (ESHRE) 21st Annual meeting
(Copenhagen, Denmark)		 2005
Travel grand award, 8th International Congress of Andrology (Seoul, South Korea) 2005
Young Scientist Award Nominee, ESHRE 17th Annual Meeting (Lausanne, Swiss land) 2001
Academic Scholarship, Taegu University (Taegu, South Korea) 1988 – 1990
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